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Der Cocker Club Deutschland
e.V.
informiert:
Familial Nephropathy (FN) ist beim Englisch Cocker eine tödlich verlaufende Nierenerkrankung.
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News vom 11.02.2010: |
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Antagene
hat seine Deutsche Niederlassung geschlossen. Absofort müssen Blutproben an Antagene in Frankreich gesandt werden. Der Preis beträgt 95,00 € pro Probe. FN DNA-Test für Englisch Cocker, mehr Infos von dem FN-Beauftragten des CCD |
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News vom 02.02.2007: |
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Die Fa. Antagene aus Frankreich hat für Europa die Lizenz für den FN-Gentest von der Fa. Merlogen USA erhalten. Presse Mitteilung von Antagene: FN Announcement Preisliste Anleitung FN DNA-Test für Englisch Cocker, mehr Infos von dem FN-Beauftragten des CCD |
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News vom 12.12.2006, update am 15.12.06: |
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Alle Englisch Cocker Spaniel Besitzer, die ihre Hunde bereits bei Optigen auf prcd-PRA haben testen lassen, können ihre Hunde bei Optigen auf FN (ARHN) testen lassen, eine neue Blutprobe ist nicht nötig, da Optigen von allen ECS, die auf prcd-PRA getestet wurden, Blutproben tiefgefroren hat. Besitzer, die ihre Hunde noch nicht auf prcd-PRA haben testen lassen, müssen warten, bis ein Europäischer Lizenznehmer gefunden ist. Der Test kostet 95,00 US$, also ca. 73,00 Euro. Wird der Test anlässlich einer Clinic gemacht und das Formular online ausgefüllt kostet der Test nur noch 71,25 US$ oder ca. 55,00 Euro. FN DNA-Test für Englisch Cocker, mehr Infos von dem FN-Beauftragten des CCD |
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Original News von Optigen: December 12, 2006 FN - Familial Nephropathy for English Cocker Spaniels OptiGen is pleased to announce that on December 8th it obtained a license from Merlogen, LLC for the genetic test for an inherited kidney disease referred to as Familial Nephropathy or "FN" (also referred to as Autosomal Hereditary Recessive Nephropathy (AHRN) [Korrekt wäre: autosomal recessive hereditary nephropathy (ARHN)] in canines and as Alport's Syndrome in humans). We expect to have complete information about the test and ordering details available on this website by December 20th. Please check back later for updates. The ECSCA website will also post updated information soon. Please note that due to contractual agreements with Merlogen, OptiGen is not allowed to test any new FN samples from Europe or Australia. We are allowed to test FN in samples that we have already received from these areas. OptiGen has retained frozen samples from all ECS PRA tests done previously, and we've decided to make these available for FN testing, even if the owner did not pay the fee for long-term storage. We hope this will help many obtain the new FN test more easily. |
FN Research News
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Cause of Autosomal Recessive Hereditary Nephropathy Found in English Cocker Spaniels The AKC Canine Health Foundation announces that Dr. Keith Murphy's laboratory has identified the genetic cause of autosomal recessive hereditary nephropathy (ARHN) in the English Cocker Spaniel (ECS). Dr. Murphy is a Professor in the Department of Pathobiology at the College of Veterinary Medicine and Biomedical Sciences of Texas A&M University and has been funded by the CHF for various projects. This work was carried out in collaboration with Dr. George Lees, Professor of Medicine, Department of Small Animal Clinical Sciences at the College of Veterinary Medicine and Biomedical Sciences of Texas A&M. Ashely Davidson, a doctoral student in the Murphy laboratory, performed the experiments and is first author on the manuscript describing this work. The availability and appropriate use of a genetic test for this mutation will permit ECS breeders to make informed decisions regarding matings and help to eradicate the disease. HN is an hereditary disease of the type IV collagens similar to Alport syndrome in humans. It can be inherited in three fashions: X-linked is the most common, autosomal recessive occurrs less frequently, and autosomal dominant is rare. An autosomal recessive form of HN was described in the ECS more than 50 years ago. Dogs affected with HN develop juvenile end stage renal failure; however, carrier dogs that carry only one mutated allele do not show symptoms of the disease. Sequence analysis of the COL4*4 gene revealed a single base substitution causing a premature stop codon. Testing for the presence of this mutation in the ECS population will allow for the identification of carrier dogs. Once carriers of the disease are identified, they can be mated to dogs that do not carry the causative allele. The patented genetic test for ARHN in the ECS is currently being licensed to a corporation and will be made available for ECS dogs. These results were announced at the English Cocker Spaniel Breed Club of America national specialty on May 11th, 2006. |
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